The diagnoses of cancer has been constantly growing exponentially every year. The statistics on the amount of diagnosed patients with cancer has shown a large increase with a projection of 22 million cases within the next two decades. The current treatments for this deadly disease has many complications and side-effects that go along with it. Even though the benefits may outweigh the cost, the cost are still detrimental to one’s health. Treatments such as surgery or chemotherapy have been associated with several symptoms such as fatigue, infection, and anemia. Research has been trying to look into different drugs and treatments for cancer that would better patient satisfaction and outcome, but has had little progress. By looking into a more physical approach by using nanotechnology, cancer treatment and prevention will improve in the future.

The nanobot would be made out of Nitinol, an alloy made up of nickel and titanium. This alloy has very high biocompatibility, so the likelihood that the body would reject it is very low. The alloy has the property to deform at a certain temperature and then return to its original shape, which can be used to be implanted into the body in a smaller size, then expanding to its full design as it enters the body. The nanobot would contain chambers with thick coated cancer killing chemicals such as pseudomonas exotoxin, diphtheria toxin, or ricin. This process will allow these conjugates of the toxins to bind to certain sites on the surface of a cancer cell, allowing the chemical to internalize and enter into the cytoplasm making it very lethal. Through the use of computer programming and various tests like nuclear medicine and 3D MRI’s, the information will be entered into the nanobot system allowing full sight of the body and control of the nanobot. To enable the movement of the nanobot, there will be the use of a motor in order to propel itself through the body and robotic legs that would allow the nanobot to stick to the walls for extreme precision when attacking. The process goes from dissecting cancer tissue, going through the toxic chambers, and then leaving the robot allowing microphages to recover the dead tissue.

This nanobot technology will be able to target and kill cancer cells within the body to halt the spread of cancer. By having a design similar to the dynamics of a bacteriophage, these nanobots will be able to perform its task in a controlled and highly effective way. With the controlled protein chemicals, there will be minimal risk factor in this type of treatment. This organized and systematic way of destroying cancer cells will be more reliable since physicians will be able to control the nanobot and its tasks. This is a better treatment than chemotherapy or invasive procedures since there are no major side effects or dangerous risks in the process. In the end, by using this nanotechnology, patients diagnosed with cancer will have improved outcomes, in addition to significantly less complications than current treatments.

*Model can be provided if requested*



Author: Austin Truong

Coauthor(s): Austin Truong, Michael Shiraishi

Status: Project Concept